Dr Nina Rogers: all content

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Frailty is an independent predictor of incident dementia: Evidence from the English Longitudinal Study of Ageing

Journal article

The aim of this study was to determine whether frailty in older adults is associated with the risk of subsequent dementia. A total of 8,722 older adults from the English Longitudinal Study of Ageing were followed-up every two years until they reported a diagnosis of dementia, died, or were right censored. Frailty was defined using a frailty index comprised of 47 health deficits. To test if cognitive function influences the relationship between frailty and incident dementia, the analyses were repeated according to lower or upper three quartiles of baseline cognitive function. Competing risks regression and Cox proportional hazard models were used to evaluate whether the degree of baseline frailty was associated with incident dementia. Compared with non-frail participants, pre-frail (HR: 1.51 95%CI [1.12–2.02]) and frail participants (HR: 1.73 95%CI [1.22–2.43]) had a higher risk of developing dementia, after adjustment for covariates. The association between frailty and incident dementia was significant for adults in the upper three quartiles of global cognitive function (HR: 3.48 95%CI [1.98–6.12]), but not for adults who were in the lowest quartile of cognitive function (HR: 1.13 95%CI [0.74–1.71]). Frailty should be monitored alongside cognitive functioning when assessing risk factors for dementia in older adults

16 November 2017

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English Longitudinal Study of Aging (ELSA). In: Nancy A Pachana (ed.). Encyclopedia of Geropsychology. Springer, Singapore.

Book Chapter
Abstract: Definition The English Longitudinal Study of Ageing (ELSA) [1] is a multidisciplinary panel study that collects a comprehensive array of measures on a representative sample of men and woman aged 50 and over who are living in England. Repeated measures covering health, economics, psychology, lifestyle and social connections are collected from the same individuals over time, allowing researchers to study the dynamics of the ageing process. The ELSA sample and study design ELSA is sampled from the Health Survey for England (HSE), a large annual cross-sectional survey on the health of the population of England [2]. Sample members recruited at wave 1 (2002/2003) were individuals who had previously taken part in one of three years of the HSE (1998, 1999 and 2001), and were aged 50 or over at the time of the wave 1 interview. Subsequent ELSA data collection waves have taken place biennially, in 2004/05 (Wave 2), 2006/07 (Wave 3), 2008/09 (Wave 4), 2010/11 (Wave 5), 2012/13 (Wave 6) and 2014/15 (Wave 7). The eighth and ninth waves of data collection are planned for 2016/17 and 2018/2019, respectively. New study participants are recruited during some waves in order to compensate for the ageing sample population and to refresh the younger age groups. This serves to maintain representation of all ages 50 and over in ELSA. Refreshment sampling to date has recruited members aged 50-52 at wave 3 (HSE 2001-04); aged 50-74 at wave 4 (HSE 2006), aged 50-55 at wave 6 (HSE 2009 -11) and aged 50-51 at Wave 7 (HSE 2011-12), with plans to continue to recruit new sample members aged 50-51 at future waves. The “core members” of the ELSA sample are individuals aged 50 and over, living in private residences, who were recruited through HSE at either the first Wave of ELSA or at any of the subsequent refreshment samples. The data also includes interviews with “young partners”, who are individuals under the age of 50 whose partners are core members and “new partners” in the correct age range who entered relationships with core members after those members were recruited to ELSA. Mode of interview Data are collected from respondents in their own home, every two years and by means of a computer assisted personal interview (CAPI) that is delivered by a trained interviewer. The CAPI includes questions on the respondents’ demographics, household membership, work and retirement activities, economic circumstances, health and behaviour. A self-completion questionnaire includes questions on wellbeing, social participation, quality of life and social networks, along with questions considered to be sensitive. The main interview takes approximately 85 minutes to complete for an individual interview and around two hours when two people within the same household are interviewed concurrently. At waves 2, 4 and 6, core members who completed a main interview were offered a visit from a qualified nurse, where a blood sample was taken and a series of performance and biomedical tests were conducted. The nurse visits took place soon after the main interviews and were of similar duration to the main interviews.

1 May 2017

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The English Longitudinal Study of Ageing, Encyclopedia of Geropsychology

Journal article

The English Longitudinal Study of Ageing (ELSA) (Steptoe et al. 2013a) is a multidis- ciplinary panel study that collects a comprehensive array of measures on a representative sample of men and woman aged 50 and over who are living in England. Repeated measures covering health, economics, psychology, lifestyle, and social connections are collected from the same individuals over time, allowing researchers to study the dynamics of the aging process.

9 January 2017

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English Longitudinal Study of Aging (ELSA)

Book Chapter
The English Longitudinal Study of Ageing (ELSA) is a multidisciplinary panel study that collects a comprehensive array of measures on a representative sample of men and woman aged 50 and over who are living in England. Repeated measures covering health, economics, psychology, lifestyle and social connections are collected from the same individuals over time, allowing researchers to study the dynamics of the ageing process.

15 April 2016

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Volunteering is associated with increased survival in able-bodied participants of the English Longitudinal Study of Ageing

Journal article
BACKGROUND: Volunteering has been linked to reduced mortality in older adults, but the mechanisms explaining this effect remain unclear. This study investigated whether volunteering is associated with increased survival in participants of the English Longitudinal Study of Ageing and whether differences in survival are modified by functional disabilities. METHODS: A multivariate Cox Proportional Hazards model was used to estimate the association of volunteering with survival over a period of 10.9 years in 10 324 participants, while controlling for selected confounders. To investigate effect modification by disability, the analyses were repeated in participants with and without self-reported functional disabilities. RESULTS: Volunteering was associated with a reduced probability of death from all causes in univariate analyses (HR=0.65, CI 0.58 to 0.73, p<0.0001), but adjustment for covariates rendered this association non-significant (HR=0.90, CI 0.79 to 1.01, p=0.07). Able-bodied volunteers had significantly increased survival compared with able-bodied non-volunteers (HR=0.81, 95% CI 0.69 to 0.95, p=0.009). There was no significant survival advantage among disabled volunteers, compared with disabled non-volunteers (HR=1.06, CI 0.88 to 1.29, p=0.53). CONCLUSIONS: BACKGROUND: Volunteering has been linked to reduced mortality in older adults, but the mechanisms explaining this effect remain unclear. This study investigated whether volunteering is associated with increased survival in participants of the English Longitudinal Study of Ageing and whether differences in survival are modified by functional disabilities. METHODS: A multivariate Cox Proportional Hazards model was used to estimate the association of volunteering with survival over a period of 10.9 years in 10 324 participants, while controlling for selected confounders. To investigate effect modification by disability, the analyses were repeated in participants with and without self-reported functional disabilities. RESULTS: Volunteering was associated with a reduced probability of death from all causes in univariate analyses (HR=0.65, CI 0.58 to 0.73, p<0.0001), but adjustment for covariates rendered this association non-significant (HR=0.90, CI 0.79 to 1.01, p=0.07). Able-bodied volunteers had significantly increased survival compared with able-bodied non-volunteers (HR=0.81, 95% CI 0.69 to 0.95, p=0.009). There was no significant survival advantage among disabled volunteers, compared with disabled non-volunteers (HR=1.06, CI 0.88 to 1.29, p=0.53). CONCLUSIONS: Volunteering is associated with reduced mortality in older adults in England, but this effect appears to be limited to volunteers who report no disabilities.

25 January 2016